Open AccessAtorvastatin regulates the migration and invasion of prostate cancer through the epithelial-mesenchymal transformation and matrix metalloproteinase pathways
Author(s) -
Zhanmeng Zhu,
Yin Cao,
Lingyun Liu,
Zhiyi Zhao,
Hongyu Yin,
Hongliang Wang
Publication year - 2022
Publication title -
investigative and clinical urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.653
H-Index - 14
eISSN - 2466-054X
pISSN - 2466-0493
DOI - 10.4111/icu.20210411
Subject(s) - cancer research , apoptosis , matrix metalloproteinase , metastasis , cell migration , cell growth , flow cytometry , matrix metalloproteinase inhibitor , cell , medicine , prostate cancer , biology , cancer , microbiology and biotechnology , biochemistry
Our purpose was to verify the effects of atorvastatin (ATO) on prostate cancer (PCa) proliferation, apoptosis, invasion, and metastasis and to further explore the drug's mechanism of action.