Open AccessAssociation of immunohistochemical markers of tumor subtype with response to neoadjuvant chemotherapy and survival in patients with muscle-invasive bladder cancer
Author(s) -
Abolfazl Razzaghdoust,
Mahdi Ghajari,
Abbas Basiri,
Peyman Mohammadi Torbati,
Anya Jafari,
Mohammad Reza Fattahi,
Maryam Salahi,
Bahram Mofid
Publication year - 2021
Publication title -
investigative and clinical urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.653
H-Index - 14
eISSN - 2466-054X
pISSN - 2466-0493
DOI - 10.4111/icu.20200425
Subject(s) - medicine , bladder cancer , immunohistochemistry , tissue microarray , oncology , proportional hazards model , hazard ratio , chemotherapy , biomarker , logistic regression , cancer , pathology , confidence interval , biochemistry , chemistry
A readily accessible biomarker to identify which patients with bladder cancer are more likely to respond to neoadjuvant chemotherapy (NAC) could help clinicians avoid unnecessary chemotherapy and prevent its subsequent complications in some patients. The primary objective of this study was to investigate the association of immunohistochemical markers of tumor subtype with response to NAC and survival of patients with muscle-invasive bladder cancer (MIBC).