Open AccessEffect of phosphodiesterase type 5 inhibitors on sperm motility and acrosome reaction: An in vitro study
Author(s) -
Seung Hun Song,
Dong Hyuk Shin,
Young Sun Her,
Mi Hee Oh,
Jung Won Baek,
Suye Sung,
Jin Hee Eum,
Yohan Heo,
Dong Suk Kim
Publication year - 2021
Publication title -
investigative and clinical urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.653
H-Index - 14
eISSN - 2466-054X
pISSN - 2466-0493
DOI - 10.4111/icu.20200394
Subject(s) - sperm , tadalafil , sperm motility , sildenafil , andrology , acrosome reaction , medicine , motility , semen , cgmp specific phosphodiesterase type 5 , semen analysis , endocrinology , infertility , biology , pregnancy , genetics
Phosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive effects of PDE5 inhibitors on semen parameters as well. However, the data are still controversial. We investigated the effect of PDE5 inhibitors on sperm function by analyzing sperm motility and acrosome reaction.