Open AccessTranscriptional profiling of mouse cavernous pericytes under high-glucose conditions: Implications for diabetic angiopathy
Author(s) -
Guo Nan Yin,
Jitao Wu,
Yuanshan Cui,
Lin Chen,
Lei Shi,
Zhenli Gao,
Jung Kook Suh,
Hai Jin
Publication year - 2021
Publication title -
investigative and clinical urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.653
H-Index - 14
eISSN - 2466-054X
pISSN - 2466-0493
DOI - 10.4111/icu.20200272
Subject(s) - microarray , gene expression , medicine , gene expression profiling , diabetes mellitus , gene , western blot , microarray analysis techniques , angiopathy , pathogenesis , pathology , cancer research , endocrinology , biology , genetics
Penile erection requires integrative interactions between vascular endothelial cells, pericytes, smooth muscle cells, and autonomic nerves. Furthermore, the importance of the role played by pericytes in the pathogenesis of angiopathy has only recently been appreciated. However, global gene expression in pericytes in diabetes mellitus-induced erectile dysfunction (DMED) remains unclear. We aimed to identify potential target genes related to DMED in mouse cavernous pericytes (MCPs).