Open AccessSuppression of CD81 promotes bladder cancer cell invasion through increased matrix metalloproteinase expression via extracellular signal-regulated kinase phosphorylation
Author(s) -
Hyun Sik Park,
Suhyuk Lee,
Jisu Lee,
Hyun Bin Shin,
Sang Wook Yoo,
MyungShin Lee,
Jinsung Park
Publication year - 2019
Publication title -
investigative and clinical urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.653
H-Index - 14
eISSN - 2466-054X
pISSN - 2466-0493
DOI - 10.4111/icu.2019.60.5.396
Subject(s) - cd81 , gene knockdown , mapk/erk pathway , cancer research , transfection , cell culture , blot , zymography , matrix metalloproteinase , kinase , extracellular matrix , microbiology and biotechnology , signal transduction , biology , immunology , biochemistry , hepatitis c virus , virus , genetics , gene
CD81 is a prognostic biomarker for high-grade bladder cancer (BC). In this study, we aimed to determine the functional mechanisms underlying the role of CD81 in BC progression.