Open AccessIntravitreal aflibercept combined with transpupillary thermotherapy in the treatment of refractory macular edema due to primary uveal melanoma
Author(s) -
Chun-Ju Lin,
YuTe Huang,
Ning-Yi Hsia,
Chun-Ting Lai,
Henry Bair,
Yi–Yu Tsai
Publication year - 2022
Publication title -
taiwan journal of ophthalmology
Language(s) - English
Resource type - Journals
eISSN - 2211-5072
pISSN - 2211-5056
DOI - 10.4103/tjo.tjo_44_21
Subject(s) - medicine , aflibercept , macular edema , fundus photography , ophthalmology , optical coherence tomography , edema , refractory (planetary science) , fundus (uterus) , fluorescein angiography , bevacizumab , surgery , retinal , chemotherapy , physics , astrobiology
We reported a 74 year old Asian female with a uveal tumor with subretinal fluid (SRF) and cystoid macula edema. Since she declined biopsy, multimodal imaging study was performed, including fundus photography, ultrasonography, optical coherence tomography, fluorescein angiography, and magnetic resonance imaging. Uveal melanoma was diagnosed. However, despite aggressive treatment with TTT and three adjuvant intravitreal bevacizumab doses, SRF, and cystoid macula edema were persistent. Therefore, aflibercept was administered, resulting in anatomical and functional improvement within 1 month, which lasted for 12 months. Aflibercept offered great efficacy in improving refractory macular edema in this case of primary uveal melanoma. Multimodal imaging can provide us with more diagnostic clues in differentiating the nature of intraocular tumors.