Open AccessKnudson to embryo selection: A story of the genetics of retinoblastoma
Author(s) -
Vrushali Athavale,
Vikas Khetan
Publication year - 2018
Publication title -
taiwan journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.519
H-Index - 9
eISSN - 2211-5072
pISSN - 2211-5056
DOI - 10.4103/tjo.tjo_37_18
Subject(s) - retinoblastoma , mendelian inheritance , genetics , medicine , inheritance (genetic algorithm) , selection (genetic algorithm) , malignancy , heredity , evolutionary biology , biology , gene , artificial intelligence , computer science
Retinoblastoma, the most common primary intraocular malignancy of the young, is a prototype hereditary cancer. Due to its fairly predictable Mendelian inheritance, easily examinable tumors, and early age of presentation, RB has served as the most extensively studied model for genetics in cancer. The genetic strides in RB have progressed at an exponential rate since the 1970s. The highly morbid, reasonably curable and distinctly predictable inheritance pattern of RB; not to mention its propensity to affect our young, forms the basis of aggressively encouraging genetic diagnosis in all patients of RB. In this article, we present the basic and clinically relevant concepts of the genetics retinoblastoma.