Open AccessRole of glucuronidation pathway in quetiapine metabolism: An in vivo drug–drug interaction study between quetiapine and probenecid
Author(s) -
Harse Sattar,
Sarmad Sheraz Jadoon,
Yang Ni,
Shihong Li,
Mingzhen Xu,
Yong Han,
Adil Ramzan,
Weiyong Li
Publication year - 2020
Publication title -
saudi journal of medicine and medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 2
eISSN - 1658-631X
pISSN - 2321-4856
DOI - 10.4103/sjmms.sjmms_441_19
Subject(s) - quetiapine , probenecid , glucuronidation , pharmacology , pharmacokinetics , cmax , quetiapine fumarate , medicine , drug metabolism , drug , chemistry , atypical antipsychotic , enzyme , biochemistry , antipsychotic , schizophrenia (object oriented programming) , microsome , psychiatry
Uridine 5'-diphospho-glucuronosyltransferase (UGT) enzymes play a significant role in the metabolism of quetiapine, and coadministration with a UGT inhibitor/inducer drug may change its pharmacokinetic profile.