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Uridine 5'-diphospho-glucuronosyltransferase (UGT) enzymes play a significant role in the metabolism of quetiapine, and coadministration with a UGT inhibitor/inducer drug may change its pharmacokinetic profile.

Role of glucuronidation pathway in quetiapine metabolism: An in vivo drug–drug interaction study between quetiapine and probenecid