Open AccessLncRNA NEAT1 modulates sorafenib resistance in hepatocellular carcinoma through regulating the miR-149-5p/AKT1 axis
Author(s) -
Yuexiang Niu,
Gongen Tang,
Xiuli Wu,
Chaoyu Wu
Publication year - 2020
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/sjg.sjg_4_20
Subject(s) - sorafenib , hepatocellular carcinoma , microrna , cancer research , akt1 , transfection , cell culture , medicine , cell , oncology , biology , signal transduction , gene , pi3k/akt/mtor pathway , microbiology and biotechnology , genetics
The purpose of this study is to explore the expression characteristics of lncRNA NEAT1 in hepatocellular carcinoma (HCC) and the molecular mechanism of its regulation on sorafenib resistance.