Open AccessCorrelated non-nuclear COX2 and low HER2 expression confers a good prognosis in colorectal cancer
Author(s) -
Feifei Zhou,
Rong Huang,
Jun Jiang,
Xin Zeng,
Shu-qian Zou
Publication year - 2018
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/sjg.sjg_46_18
Subject(s) - colorectal cancer , medicine , immunohistochemistry , oncology , cancer , stage (stratigraphy) , cancer research , biology , paleontology
COX2 and HER2 are shown to be critical in the regulation of cancer progression. However, the prognostic value of nuclear COX2 in colorectal cancer (CRC) and its relationship with HER2 still remains unknown. In this study, the expression and biological significance of COX2 and HER2 were evaluated in CRC at mRNA and protein levels.