Open AccessHelicobacter pylori DNA promotes cellular proliferation, migration, and invasion of gastric cancer by activating toll-like receptor 9
Author(s) -
Xiang-Rong Qin,
Jack Wu,
Xinyu Yao,
Jin Huang,
Xiaoyong Wang
Publication year - 2019
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/sjg.sjg_309_18
Subject(s) - tlr9 , helicobacter pylori , gene knockdown , cancer research , downregulation and upregulation , cell growth , cancer cell , cancer , toll like receptor 9 , cell , biology , medicine , immunology , cell culture , gene expression , gene , biochemistry , genetics , dna methylation
Helicobacter pylori (H. pylori) infection is a well-known risk factor for gastric cancer. Toll-like receptor 9 (TLR9) plays an important role in many cancers and is important for immunity to H. pylori infection. Thus, the present study aimed to evaluate the influence of H. pylori on TLR9 and explore its roles in gastric cancer.