Open AccessThe Level of TWIST1 expression determines the response of colon cancer cells to mitogen-activated protein kinases inhibitors
Author(s) -
Tomasz Przybyła,
Martyna Wesserling,
Monika Sakowicz-Burkiewicz,
Izabela Maciejewska,
Tadeusz Pawełczyk
Publication year - 2018
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/sjg.sjg_270_17
Subject(s) - colorectal cancer , medicine , kinase , mapk/erk pathway , cancer , gene silencing , p38 mitogen activated protein kinases , cancer research , mitogen activated protein kinase , cancer cell , oncology , biology , microbiology and biotechnology , biochemistry , gene
Currently, it has been proposed that combination of 5-fluorouracil (5FU) with inhibitors of the mitogen-activated protein kinases (MAPKs) signaling pathway might enhance the efficacy of 5FU-based chemotherapy in colon cancer. Our study aimed to investigate an impact of TWIST1 silencing on the sensitivity of cancer cells to 5FU and selected MAPK inhibitors.