Open AccessExtended release granisetron: Review of pharmacologic considerations and clinical role in the perioperative setting
Author(s) -
Anh L. Ngo,
Vwaire Orhurhu,
Ivan Urits,
Edwin O Delfin,
Medha Sharma,
Mark R. Jones,
Omar Viswanath,
Richard D. Urman
Publication year - 2019
Publication title -
saudi journal of anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.416
H-Index - 24
eISSN - 1658-354X
pISSN - 0975-3125
DOI - 10.4103/sja.sja_817_18
Subject(s) - granisetron , medicine , metoclopramide , droperidol , antiemetic , ondansetron , perioperative , promethazine , anesthesia , postoperative nausea and vomiting , intensive care medicine , dexamethasone , nausea , vomiting
In this review, we evaluate recent literature on use of ER granisetron in clinical practice as compared with current antiemetics and describe its potential uses for perioperative PONV prophylaxis and treatment. Recent literature was evaluated on ER granisetron use compared with currently used antiemetic agents ondansetron, droperidol, metoclopramide, promethazine, and dexamethasone with a focus on procedural anti-emesis. Though promising great effect, application of extended release granisetron to clinical use may be limited by it's increased relative cost.