Open AccessUsing propranolol in traumatic brain injury to reduce sympathetic storm phenomenon: A prospective randomized clinical trial
Author(s) -
Mona Ahmed Ammar,
Noha Sayed Hussein
Publication year - 2018
Publication title -
saudi journal of anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.416
H-Index - 24
eISSN - 1658-354X
pISSN - 0975-3125
DOI - 10.4103/sja.sja_33_18
Subject(s) - medicine , propranolol , anesthesia , traumatic brain injury , blood pressure , heart rate , tachypnea , catecholamine , glasgow coma scale , interquartile range , norepinephrine , placebo , epinephrine , tachycardia , dopamine , alternative medicine , pathology , psychiatry
Traumatic brain injury (TBI) correlated with increased sympathetic activity on the expense of parasympathetic system due to loss of cortical control after brain injury. Manifestations of sympathetic storm include tachycardia, hypertension, tachypnea, and hyperthermia. The neuroprotective effects via reducing cerebral metabolism and lowering O 2 and glucose consumption are the targets early after trauma. Beta-blockers reduce sympathetic activity.