Open AccessMarine-derived fungi extracts enhance the cytotoxic activity of doxorubicin in nonsmall cell lung cancer cells A459
Author(s) -
Bruno CastroCarvalho,
Altina Ramos,
Maria PrataSena,
Fernanda Malhão,
Márcia Zabdiele Moreira,
Daniela Longo Gargiulo,
Tida Dethoup,
Suradet Buttachon,
Anake Kijjoa,
Eduardo Rocha
Publication year - 2017
Publication title -
pharmacognosy research
Language(s) - English
Resource type - Journals
eISSN - 0976-4836
pISSN - 0974-8490
DOI - 10.4103/pr.pr_57_17
Subject(s) - cytotoxic t cell , doxorubicin , lung cancer , cytotoxicity , cancer , cancer research , biology , pharmacology , medicine , oncology , chemotherapy , biochemistry , in vitro
Drug resistance is a major concern in the current chemotherapeutic approaches and the combination with natural compounds may enhance the cytotoxic effects of the anticancer drugs. Therefore, this study evaluated the cytotoxicity of crude ethyl extracts of six marine-derived fungi - Neosartorya tsunodae KUFC 9213 (E1), Neosartorya laciniosa KUFC 7896 (E2), Neosartorya fischeri KUFC 6344 (E3), Aspergillus similanensis KUFA 0013 (E4), Neosartorya paulistensis KUFC 7894 (E5), and Talaromyces trachyspermum KUFC 0021 (E6) - when combined with doxorubicin (Dox), in seven human cancer cell lines.