Open AccessProtective effect of Withania coagulans fruit extract on cisplatin-induced nephrotoxicity in rats
Author(s) -
Sonam Sharma,
A. C. Joshi,
S Hemalatha
Publication year - 2017
Publication title -
pharmacognosy research
Language(s) - English
Resource type - Journals
eISSN - 0976-4836
pISSN - 0974-8490
DOI - 10.4103/pr.pr_1_17
Subject(s) - nephrotoxicity , cisplatin , pharmacology , oxidative stress , kidney , toxicity , superoxide dismutase , chemistry , glutathione , antioxidant , creatinine , medicine , biochemistry , chemotherapy , enzyme , organic chemistry
Fruits of Withania coagulans ( Solanaceae ) reported to possess several bioactive compounds as curative agents for various clinical conditions. Cisplatin is a chemotherapeutic drug to treat sarcomas, carcinomas, lymphomas, cervical cancer, germ cell tumors, etc. The major factor that limits its clinical use is its dose-dependent nephrotoxicity.