Open AccessAntioxidant and cholinesterase inhibitory activities of ethyl acetate extract of Terminalia chebula: Cell-free In vitro and In silico studies
Author(s) -
Rajmohamed Mohamed Asik,
Natarajan Suganthy,
Premkumar Palanisamy,
A.M. Abdul-Kader,
Govindaraju Archunan
Publication year - 2017
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/pm.pm_57_17
Subject(s) - terminalia chebula , cholinesterase , antioxidant , in silico , in vitro , chemistry , ethyl acetate , pharmacology , traditional medicine , inhibitory postsynaptic potential , biochemistry , biology , medicine , neuroscience , gene
Alzheimer's disease (AD) is a progressive neurodegenerative disorder clinically characterized by memory loss and impaired cognitive function. Cholinergic enzyme deficiency and oxidative stress are the two major factors implicated in the pathogenesis of AD. The symptomatic treatment, as of now, is the use of cholinesterase inhibitors toward cholinergic "downturn." Therefore, there is a search for compounds that will be useful in focused therapies. There has been suggestion that Terminalia chebula fruit would be a potential source.