Open AccessDocking-based screening of Ficus religiosa phytochemicals as inhibitors of human histamine H2 receptor
Author(s) -
Amit Chaudhary,
Birendra Singh Yadav,
Vijay Pratap Singh,
Pramod Kumar Maurya,
Alok Mishra,
Shweta Srivastva,
Pritish Kumar Varadwaj,
Nand Kumar Singh,
Ashutosh Mani
Publication year - 2017
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/pm.pm_49_17
Subject(s) - lanosterol , histamine , histamine receptor , docking (animal) , pharmacology , chemistry , receptor , homology modeling , stereochemistry , biochemistry , biology , enzyme , medicine , antagonist , sterol , nursing , cholesterol
Ficus religiosa L. is generally known as Peepal and belongs to family Moraceae . The tree is a source of many compounds having high medicinal value. In gastrointestinal tract, histamine H2 receptors have key role in histamine-stimulated gastric acid secretion. Their over stimulation causes its excessive production which is responsible for gastric ulcer.