Open AccessIngenine F: A new cytotoxic tetrahydro carboline alkaloid from the Indonesian marine sponge Acanthostrongylophora ingens
Author(s) -
Sabrin R. M. Ibrahim,
Gamal A. Mohamed,
Rwaida A. Al Haidari,
Amal A. El-Kholy,
Mohamed F. Zayed
Publication year - 2018
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/pm.pm_489_17
Subject(s) - alkaloid , chemistry , cytotoxic t cell , stereochemistry , ic50 , glycocholic acid , chromatography , biochemistry , cholic acid , in vitro , bile acid
Marine organisms are established to be a wealthy source of bioactive compounds with diverse chemical structures and bioactivities. Acanthostrongylophora ingens is known to be rich with pyrimidine b-carboline and manzamine-type alkaloids. The goal of the present work is to isolate and identify new alkaloids from A. ingens as well as to assess the cytotoxic potential of these metabolites towards various cancer cell lines.