Open AccessBioassay-guided isolation of neuroprotective fatty acids from Nigella sativa against 1-methyl-4-phenylpyridinium-induced neurotoxicity
Author(s) -
Leila Hosseinzadeh,
Hoda Monaghash,
Farahnaz Ahmadi,
Nastaran Ghiasvand,
Yalda Shokoohinia
Publication year - 2017
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/pm.pm_470_16
Subject(s) - neurotoxicity , neuroprotection , linoleic acid , apoptosis , biochemistry , chemistry , nigella sativa , pharmacology , programmed cell death , fatty acid , biology , toxicity , medicine , traditional medicine , organic chemistry
Parkinson's disease, a slowly progressive neurological disease, is associated with degeneration of the basal ganglia of the brain and a deficiency of the neurotransmitter dopamine. The main aspects of researches are the protection of normal neurons against degeneration. Fatty acids (FAs), the key structural elements of dietary lipids, are carboxylic straight chains and notable parameters in nutritional and industrial usefulness of a plant.