Open AccessRapid screening and characterization of acetylcholinesterase inhibitors from Yinhuang oral liquid using ultrafiltration-liquid chromatography-electrospray ionization tandem mass spectrometry
Author(s) -
Haomin Zhang,
Yinan Guo,
Lingjun Meng,
Hui Sun,
Yinping Yang,
Ying Gao,
Jiaming Sun
Publication year - 2018
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/pm.pm_166_17
Subject(s) - chromatography , chemistry , acetylcholinesterase , electrospray ionization , ultrafiltration (renal) , mass spectrometry , liquid chromatography–mass spectrometry , tandem mass spectrometry , high performance liquid chromatography , enzyme , biochemistry
At present, approximately 17-25 million people in the world suffer from Alzheimer's disease (AD). The most efficacious and acceptable therapeutic drug clinically are the acetylcholinesterase inhibitors (AChEIs). Yinhuang oral liquid is a Chinese medicine preparation which contains AChEIs according to the literatures. However, no strategy has been presented for rapid screening and identification of AChEIs from Yinhuang oral liquid.