Open AccessChalepin: A compound from Ruta angustifolia L. pers exhibits cell cycle arrest at S phase, suppresses nuclear factor-kappa B (NF-κB) pathway, signal transducer and activation of transcription 3 (STAT3) phosphorylation and extrinsic apoptotic pathway in non-small cell lung cancer carcinoma (A549)
Author(s) -
Jaime Stella Moses Richardson,
Norhaniza Aminudin,
Sri Nurestri Abd Malek
Publication year - 2017
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/pm.pm_13_17
Subject(s) - stat3 , transcription factor , phosphorylation , cell cycle checkpoint , microbiology and biotechnology , nfkb1 , nf κb , kappa , chemistry , biology , signal transduction , cell cycle , biochemistry , cell , gene , linguistics , philosophy
Plants have been a major source of inspiration in developing novel drug compounds in the treatment of various diseases that afflict human beings worldwide. Ruta angustifolia L. Pers known locally as Garuda has been conventionally used for various medicinal purposes such as in the treatment of cancer.