Open AccessThe changing perspective of clinical trial designs
Author(s) -
Yamini Ajmera,
Sunny Singhal,
Shashank Dwivedi,
Aparajita Dey
Publication year - 2021
Publication title -
perspectives in clinical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.649
H-Index - 8
eISSN - 2229-5488
pISSN - 2229-3485
DOI - 10.4103/picr.picr_138_20
Subject(s) - clinical trial , strengths and weaknesses , clinical study design , globe , alternative medicine , effi , population , risk analysis (engineering) , perspective (graphical) , medicine , computer science , management science , medical physics , psychology , engineering , environmental health , artificial intelligence , pathology , social psychology , database , ophthalmology
Maintaining health and well-being of the population is a universal priority. Governments around the globe are therefore seeking greater efficiency and better outcomes from researches being held. Although large randomized trials or systematic review of several large trials provides the highest level of evidence, the intricate cost, time, and difficulties of conventional trials have led to questions about their sustainability commanding search for alternative approaches. Demands for improved competences in medical research have led to mounting interest in newer clinical trial designs. This article provides an insight into newer clinical trial designs, including cluster trials, adaptive designs, the master protocols along with their strengths, weaknesses, and which trials design should be opted for in different clinical scenarios.