Open AccessPemphigus in sarcomatoid renal cell carcinoma: A rare paraneoplastic manifestation
Author(s) -
Amit Gupta,
Amod Gupta,
Shikha Gupta,
Prashant Durgapal,
Bina Ravi,
Rohik Anjum T Sideek
Publication year - 2020
Publication title -
nigerian journal of surgery/nigerian journal of surgery
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2278-7100
pISSN - 1117-6806
DOI - 10.4103/njs.njs_4_19
Subject(s) - renal cell carcinoma , pathology , sarcomatoid carcinoma , medicine , carcinoma , pathogenesis , kidney , nephrectomy
Renal cell carcinoma with sarcomatoid features is a rare presentation with a 5% incidence. Sarcomatoid renal cell carcinoma is usually associated with poor prognosis. It commonly metastasizes to the lungs, bones, and liver. Dermatological manifestation with paraneoplastic syndrome is extremely rare. Pathogenesis of PNP in renal cell carcinoma is not cleat; till date, however, few literature suggest antibodies against a group plakin family which plays a key role in intermediate filament attachment in RCC. We present PNP in a 64-year-old female associated with renal cell carcinoma.