Open AccessProphylactic use of pentoxifylline and tocopherol in patients undergoing dental extractions following radiotherapy for head and neck cancer
Author(s) -
Karun Aggarwal,
Manish Goutam,
Madhavi Singh,
Neetu Kharat,
Vandana Singh,
Suyash Vyas,
Harkanwal Preet Singh
Publication year - 2017
Publication title -
nigerian journal of surgery/nigerian journal of surgery
Language(s) - English
Resource type - Journals
eISSN - 2278-7100
pISSN - 1117-6806
DOI - 10.4103/njs.njs_40_16
Subject(s) - pentoxifylline , head and neck cancer , medicine , radiation therapy , tocopherol , head and neck , dentistry , oncology , surgery , vitamin e , antioxidant , biochemistry , chemistry
In head and neck cancer patients undergoing radiotherapy, osteoradionecrosis (ORN) of the jaw is one of the major but uncommon complications. Satisfactorily results have been observed while treating ORN patients with upcoming treatment modalities such as combination therapy of pentoxifylline and Vitamin E (PVe). It is believed that in patients undergoing dental extractions, these treatment modalities can be used prophylactically for lowering the risk of development of ORN. Hence, keeping all these things in mind, we planned the present study to assess the prophylactic role of pentoxifylline and tocopherol in patients who require dental extractions after radiotherapy for cancer of head and neck.