Open AccessComparison of calretinin expression in dentigerous cysts and ameloblastoma: An immunohistochemical study
Author(s) -
Anchal Varshney,
Shivani Aggarwal,
Sharanjeet Gill,
Ashim Aggarwal,
Yashmi Jaiswal,
Jyoti Sharma
Publication year - 2020
Publication title -
national journal of maxillofacial surgery
Language(s) - English
Resource type - Journals
eISSN - 2229-3418
pISSN - 0975-5950
DOI - 10.4103/njms.njms_71_19
Subject(s) - calretinin , ameloblastoma , keratocyst , dentigerous cyst , pathology , medicine , immunohistochemistry , adamantinoma , cyst , odontogenic tumor , odontogenic , anatomy , maxilla
Calretinin is a calcium-binding protein of 29-kilodalton (kDa), which is widely expressed in normal human tissues and tumorigenic tissues. Its expression in the odontogenic epithelium during odontogenesis and in neoplastic odontogenic tissues has been demonstrated. Unicystic ameloblastoma poses a diagnostic challenge, as its histologic presentation can be sometimes mistaken for cystic odontogenic lesions. In the present study, an attempt is made to overcome the confusion encountered in the diagnosis of dentigerous cyst and unicystic ameloblastoma, using the expression of calretinin in both lesions and to compare this expression with conventional ameloblastoma to accurately diagnose and differentiate these lesions.