Open AccessChemoprotective effect of nanocurcumin on 5-fluorouracil-induced-toxicity toward oral cancer treatment
Author(s) -
Saurabh Srivastava,
Shalini Gupta,
Abbas Ali Mahdi,
Rakesh Dixit,
Vibha Singh,
Firoza Samadi
Publication year - 2018
Publication title -
national journal of maxillofacial surgery
Language(s) - English
Resource type - Journals
eISSN - 2229-3418
pISSN - 0975-5950
DOI - 10.4103/njms.njms_27_18
Subject(s) - chemoprotective , pharmacology , medicine , cancer cell , viability assay , cytotoxicity , toxicity , reactive oxygen species , antioxidant , curcumin , nanocarriers , cancer , biochemistry , apoptosis , chemistry , drug , in vitro
Cancer of oral cavity is the uncontrolled expansion of damaged cell within the mouth cavity. 5-fluorouracil (5-FU) chemotherapy was focused to kill the cancer cell, but it would affect the surrounding normal cells during oral cancer treatment. This study included the evaluation of chemoprotective effects of curcumin (CU), as an herbal remedy, on 5-FU-induced-cytotoxicity toward oral cancer treatment, loaded within a nanocarrier system. CU was combined with 5-FU chemotherapy as a combinational drug-delivery system to evaluate synergistic effects.