Open AccessA randomized clinical trial evaluating the efficacy of colistin loading dose in critically ill children
Author(s) -
Shiva Fatehi,
Hamid Eshaghi,
Mohammad Sharif Sharifzadeh,
Bahador Mirrahimi,
Mostafa Qorbani,
Parin Tanzifi,
Kheirollah Gholami,
Toktam Faghihi
Publication year - 2019
Publication title -
journal of research in pharmacy practice
Language(s) - English
Resource type - Journals
eISSN - 2319-9644
pISSN - 2279-042X
DOI - 10.4103/jrpp.jrpp_19_68
Subject(s) - colistin , medicine , loading dose , dosing , clinical trial , randomized controlled trial , pharmacokinetics , critically ill , pneumonia , intensive care medicine , antibiotics , microbiology and biotechnology , biology
Pharmacokinetic and clinical studies recommend applying loading dose of colistin for the treatment of severe infections in the critically ill adults. Pharmacokinetic studies of colistin in children also highlight the need for a loading dose. However, there are no clinical studies evaluating the effectiveness of colistin loading dose in children.