Open AccessStudy of Hypoxia-inducible factor-2α expression in the malignant transformation of Oral submucous fibrosis
Author(s) -
Immanuel Joseph,
Elizabeth Joshua,
Umadevi K Rao,
Kannan Ranganathan
Publication year - 2020
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/jomfp.jomfp_42_19
Subject(s) - oral submucous fibrosis , areca , immunohistochemistry , medicine , pathology , hypoxia inducible factors , angiogenesis , hypoxia (environmental) , hif1a , cancer , fibrosis , biology , gene , chemistry , oxygen , engineering , biochemistry , structural engineering , organic chemistry , nut
Hypoxia-inducible factor (HIF)-2α is overexpressed in primary and metastatic human cancers, whose expression is correlated with tumor angiogenesis and patient mortality. HIF plays a role in the progression of fibrosis in oral submucous fibrosis (OSF).