Open AccessClear-cell variant of oral squamous cell carcinoma: A rare entity
Author(s) -
Pratibha Ramani,
S Gheena,
Monika Karunagaran,
R Hannah
Publication year - 2021
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/jomfp.jomfp_295_20
Subject(s) - pathology , cytokeratin , malignancy , immunohistochemistry , epithelium , basal cell , periodic acid–schiff stain , oral mucosa , tongue , carcinoma , medicine , cell , alveolar mucosa , biology , genetics
Clear-cell variant of oral squamous cell carcinoma is an extremely rare entity in the maxillofacial region. We report a case of 42-year-old female who presented with a soft-tissue growth with erythematous and nonscrapable irregular white patches on the left alveolar mucosa for the past 3 months. Histopathologic examination showed lobules and sheets of clear cells with features of malignancy extending from the surface epithelium. Periodic acid-Schiff and mucicarmine stains showed a negative reaction. Immunohistochemical study using antibody for pan-cytokeratin revealed intense positivity and negative for the markers such as S-100, smooth muscle actin and CD 117.