Open AccessEvaluation of aryl hydrocarbon receptor expression in oral squamous cell carcinoma and normal oral mucosa using western blot
Author(s) -
Vinod Mony,
R Madhavan Nirmal,
V. Parvathi,
R L Parvathy,
B R Varun,
P Jayanthi
Publication year - 2021
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/jomfp.jomfp_287_20
Subject(s) - aryl hydrocarbon receptor , oral mucosa , western blot , carcinogenesis , cancer research , medicine , pathology , biology , oncology , cancer , transcription factor , biochemistry , gene
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that acts as a binding site for toxic chemicals, particularly the dioxin group of chemicals. Elevated levels of AHR have been observed in various human cancers, including lung carcinomas, hepatic carcinomas and in mammary tumors. However, the expression of AHR in oral squamous cell carcinoma (OSCC) patients who are tobacco users are less explored.