Open AccessGiant-cell fibroma: Understanding the nature of the melanin-laden cells
Author(s) -
Spoorti Kulkarni,
Chetana Chandrashekar,
Ranjani Kudva,
Raghu Radhakrishnan
Publication year - 2017
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/jomfp.jomfp_209_16
Subject(s) - giant cell , stroma , histopathology , pathology , fibroma , melanin , immunohistochemistry , biology , staining , anatomy , medicine , genetics
Giant-cell fibroma is a localized, benign fibrous mucosal mass, which clinically mimics any other fibroepithelial growth, and its distinction from other lesions is on the basis of its peculiar histopathology. A case of giant-cell fibroma with stroma strewn with brown pigment-laden cells is presented herewith. Immunohistochemical staining aided with histochemical reaction to understand the origin of these cells was carried out. Various mechanisms that explain the presence of melanin granules in reactive lesions of giant-cell fibroma is discussed in the present report.