Open AccessAnalysis of expression of p53, p63 and proliferating cell nuclear antigen proteins in odontogenic keratocyst: An immunohistochemical study
Author(s) -
Vidya Kadashetti,
Nanda Patil,
Kailas D. Datkhile,
Sujata Kanetakar,
KM Shivakumar
Publication year - 2020
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/jomfp.jomfp_203_19
Subject(s) - keratocyst , proliferating cell nuclear antigen , immunohistochemistry , pathology , nevoid basal cell carcinoma syndrome , biology , odontogenic , epithelium , basal (medicine) , basal cell carcinoma , medicine , basal cell , insulin , endocrinology
Odontogenic keratocyst (OKC) is a benign intraosseous lesions (within the jaw bone) of odontogenic origin that account for about 10% of jaw cysts. They are characterized by an aggressive behavior with a relatively high recurrence rate. Early diagnosis and follow-up of the patient with OKC is important because the possibility of such patient there is develop to other features of Nevoid basal cell carcinoma syndrome in future. Considering the roles and effects of p53, p63 and proliferating cell nuclear antigen (PCNA) in cells proliferation, this study was designed.