Open AccessImmunoexperssion of cancer stem cell marker (CD44) in ameloblastoma
Author(s) -
Manjushri Madhukar Vanje,
Shafiq Tanveer,
Syed Afroz Ahmed,
Sandeep Kumar,
Tejashree Vanje
Publication year - 2019
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/jomfp.jomfp_152_17
Subject(s) - cd44 , ameloblastoma , stem cell , cancer , stem cell marker , cancer research , biology , cell , genetics , anatomy , maxilla
Ameloblastoma is the most frequently encountered benign, locally invasive tumor. Attempts to surgically resect the tumor often leave small islands of tumor, which later result in recurrence in 50%-90% of cases. This has raised questions regarding the tumor cell populations that are responsible for tumor growth and recurrence. In ameloblastoma, whether or not cancer stem-like cells are present remains undetermined. However, if cancer stem-like cells are present in ameloblastoma, it is important to identify which type of cell possesses the stem-like characteristics and is responsible for ameloblastoma progression and recurrence.