Open AccessTumor necrosis factor-like weak inducer of apoptosis expression in healthy oral mucosa, oral dysplasia and oral squamous cell carcinoma
Author(s) -
Swetha Acharya,
Prashant Prabhu,
Vijay S. Patil,
Anirudh B. Acharya,
Anil Kumar Desai,
Krithi Nikhil
Publication year - 2019
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/jomfp.jomfp_151_19
Subject(s) - immunohistochemistry , pathology , medicine , dysplasia , apoptosis , pathogenesis , tumor necrosis factor alpha , oral mucosa , tumor progression , cancer , biology , biochemistry
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) has been implicated in the pathogenesis of cancer, as it participates in the progression of internal malignancies. However, its role in the biology of squamous cell carcinoma (SCC) is uncertain. Studies regarding TWEAK in SCC have shown inconsistent results. We aimed to study the expression of TWEAK in healthy oral mucosa, oral dysplastic lesions and in oral SCC (OSCC).