Open AccessStromal desmoplasia as a possible prognostic indicator in different grades of oral squamous cell carcinoma
Author(s) -
Heena Zainab,
Ameena Sultana,
Shaimaa
Publication year - 2019
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/jomfp.jomfp_136_19
Subject(s) - desmoplasia , stroma , stromal cell , pathology , extracellular matrix , cancer cell , biology , metastasis , cancer , cancer research , medicine , immunohistochemistry , microbiology and biotechnology , genetics
One of the major aspects of tumor cell invasion and metastasis is the interaction between cancer cells and the extracellular matrix component. The invasion of epithelial tumor cells into the underlying connective tissue stroma causes dynamic changes in its microenvironment, which can be seen as radical changes in the stroma. The characteristics of the stroma in relation to the invading malignant epithelial cells and the interdependence between the stroma and the tumor cells are always a matter of discussion and interest.