Open AccessModulation of radiation-induced base excision repair pathway gene expression by melatonin
Author(s) -
Saeed Rezapoor,
Alireza Shirazi,
Saeed Abbasi,
Javad Tavakkoly Bazzaz,
Pantea Izadi,
Hamed Rezaeejam,
Majid Valizadeh,
Farid Soleimani-Mohammadi,
Masoud Najafi
Publication year - 2017
Publication title -
journal of medical physics/journal of medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.292
H-Index - 24
eISSN - 1998-3913
pISSN - 0971-6203
DOI - 10.4103/jmp.jmp_9_17
Subject(s) - xrcc1 , ionizing radiation , irradiation , dna repair , chemistry , downregulation and upregulation , dna damage , melatonin , radiation therapy , microbiology and biotechnology , andrology , cancer research , biology , gene , medicine , endocrinology , dna , biochemistry , genotype , physics , single nucleotide polymorphism , nuclear physics
Approximately 70% of all cancer patients receive radiotherapy. Although radiotherapy is effective in killing cancer cells, it has adverse effects on normal cells as well. Melatonin (MLT) as a potent antioxidant and anti-inflammatory agent has been proposed to stimulate DNA repair capacity. We investigated the capability of MLT in the modification of radiation-induced DNA damage in rat peripheral blood cells.