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In advanced radiotherapy techniques such as three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT), geometrical uncertainties are very crucial as they may lead to under dosing of tumor and over dosing of the nearby critical structures and hence, it is important to determine planning target volume (PTV) margins which are specific for every center.

journal of medical physics

Determination of optimal clinical target volume to planning target volume margins for conformal radiotherapy planning using image guidance system in rectal cancer in prone position