Open AccessBone alkaline phosphatase and urine hydroxyproline assay in pre and postmenopausal women in the state of sikkim and its correlation with bone mineral density
Author(s) -
SG Thejaswi,
AnneDeborah Rai,
Mingma Sherpa,
Amumacha T. Singh,
RinchenD Bhutia
Publication year - 2021
Publication title -
journal of mid-life health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.423
H-Index - 11
eISSN - 0976-7819
pISSN - 0976-7800
DOI - 10.4103/jmh.jmh_73_21
Subject(s) - hydroxyproline , urine , medicine , bone remodeling , osteoporosis , bone mineral , alkaline phosphatase , endocrinology , bone resorption , bone disease , metabolic bone disease , acid phosphatase , chemistry , enzyme , biochemistry
Osteoporosis could be viewed as a metabolic disease. The WHO guidelines for diagnosing osteoporosis reflect structural damage only and not the metabolic imbalance that leads to it. Biochemical markers of bone turnover have been shown to provide valuable information for diagnosing and monitoring metabolic bone disease. The present study analyzed bone-specific alkaline phosphatase (BALP) and urinary hydroxyproline in pre- and postmenopausal women and correlated them with changes in bone mineral density (BMD) in the state of Sikkim. The study also intended to know the ethnicity-based disease burden in Sikkim.