Open AccessAssociation of leukemia and mitochondrial diseases—A review
Author(s) -
Ashwani Sachdeva,
Jagadish Prasad Rajguru,
Kanwardeep Sohi,
Swati Saggar Sachdeva,
Kirandeep Kaur,
R. Nandini Devi,
Vivek Rana
Publication year - 2019
Publication title -
journal of family medicine and primary care
Language(s) - English
Resource type - Journals
eISSN - 2278-7135
pISSN - 2249-4863
DOI - 10.4103/jfmpc.jfmpc_679_19
Subject(s) - oxidative phosphorylation , medicine , mitochondrial dna , mitochondrion , leukemia , apoptosis , function (biology) , oxidative damage , cancer , energy metabolism , phosphorylation , bioinformatics , microbiology and biotechnology , cancer research , genetics , oxidative stress , gene , immunology , biochemistry , biology
Mitochondria play an important role in various metabolic pathways like oxidative phosphorylation free radical generation and apoptosis. Defects in mitochondrial function are responsible for a number of heterogenous clinical presentations along with development and progression of cancer. Decrease in cellular energy (ATP) production because of impaired oxidative phosphorylation is the most important cause for these underlying disorders. The present review article aims to provide current understanding of mitochondrial genetics and biology and relates the mt-DNA alterations in leukemia patients.