Open AccessRecurrent cerebral venous sinus thrombosis in a young man- A case report of JAK2-negative polycythemia vera
Author(s) -
Akanksha Singh,
Subodh Kumar Mahto,
Jyotsana Prasad,
Suman Sharma,
Anshoo Malhotra
Publication year - 2019
Publication title -
journal of family medicine and primary care
Language(s) - English
Resource type - Journals
eISSN - 2278-7135
pISSN - 2249-4863
DOI - 10.4103/jfmpc.jfmpc_628_19
Subject(s) - medicine , polycythemia vera , cerebral venous sinus thrombosis , etiology , vomiting , venous thrombosis , straight sinus , thrombosis , gastroenterology , pediatrics , cardiology , superior sagittal sinus
Polycythemia vera (PV) is a myeloproliferative disorder most commonly associated with JAK2V617F mutation. Cerebral venous sinus thrombosis (CVST) has a wide range of etiologies and PV is one of them. CVST associated with PV has a poor prognosis. Some patients with classical PV lack JAK2V617F mutation and the molecular basis of JAK2V617F -negative PV is not known. We hereby report a case of a young man who presented with headache, vomiting and altered sensorium and was found to have recurrent CSVT. The patient had primary polycythemia and was subsequently diagnosed to have JAK2 -negative PV.