Open AccessInvestigating the effect of sildenafil on improving lung function and quality of life in the patients with severe asthma
Author(s) -
Hamid Borsi,
Hanieh Raji,
Maryam Haddadzadeh Shoushtari,
Heshmatollah Tavakol,
Mohammad Hossein Haghighizadeh,
Mehrdad Dargahi-Malamir
Publication year - 2019
Publication title -
journal of family medicine and primary care
Language(s) - English
Resource type - Journals
eISSN - 2278-7135
pISSN - 2249-4863
DOI - 10.4103/jfmpc.jfmpc_334_19
Subject(s) - medicine , sildenafil , placebo , asthma , quality of life (healthcare) , pulmonary function testing , vital capacity , minimal clinically important difference , anesthesia , lung function , randomized controlled trial , lung , alternative medicine , nursing , pathology , diffusing capacity
Phosphodiesterase inhibitors (PDEs) increase intracellular cyclic adenosine monophosphate, which results in a wide range of anti-inflammatory effects and pathologically leads to improve asthma disease. Because no human study has surveyed the effect of PDEs on pulmonary function, except some case reports and animal researches, we decided to perform a pilot study for evaluating the effect of sildenafil (PDE5) on pulmonary function in patients with severe asthma.