Open AccessAbdelazim equation: For 24-h urine protein from spot urine sample in preeclampsia
Author(s) -
Ibrahim A. Abdelazim
Publication year - 2021
Publication title -
journal of family medicine and primary care
Language(s) - English
Resource type - Journals
eISSN - 2278-7135
pISSN - 2249-4863
DOI - 10.4103/jfmpc.jfmpc_2112_20
Subject(s) - urine , medicine , creatinine , proteinuria , preeclampsia , urology , pregnancy , endocrinology , kidney , biology , genetics
Measurement of 24-h urine protein (UP) is the standard method for detection of proteinuria in preeclampsia (PE). A 24-h urine sampling is time-consuming, inconvenient, and delays the diagnosis of PE. A 29-year-old woman, previous cesarean section (CS), pregnant 37 weeks' +2 days , mild PE, and another 31-year-old woman, primipara, pregnant 34 weeks' +4 days , severe PE, were admitted for control of blood pressure and termination of pregnancy. Studied women were subjected to fetal well-being assessment, routine antenatal, and laboratory investigations to exclude chronic renal diseases, and for 24-h urine sampling. A spot mid-stream urine sample was obtained shortly before the 24-h urine sampling to measure the protein/creatinine (P/C) ratio. The first studied woman had normal serum creatinine and blood urea, 688 mg protein/24-h urine, 86 mg/dL spot UP, 178 mg/dL spot urine creatinine, and 0.48 P/C ratio. The second studied woman had also normal serum creatinine and blood urea, 1199 mg protein/24-h urine, 147 mg/dL spot UP, 133 mg/dL spot urine creatinine, and 1.11 spot P/C ratio. The spot urine sample was suggested by the National Kidney Foundation to detect and monitor proteinuria in adults. Moreover, the 24-h UP can be calculated from the following equation: 24-h UP in g = P/C ratio × 0.81 + 0.3 (Abdelazim equation) without 24-h urine sampling. This report suggests the use of Abdelazim equation (24-h UP in g = P/C ratio × 0.81 + 0.3) for detection of 24-h UP from spot urine sample in PE without 24-h urine sampling.