Open AccessGliomas - An experience based on molecular markers
Author(s) -
Susmita Sarma,
Yookarin Khonglah,
Jaya Mishra,
Arindom Kakati,
Pranjal Phukan
Publication year - 2021
Publication title -
journal of family medicine and primary care
Language(s) - English
Resource type - Journals
eISSN - 2278-7135
pISSN - 2249-4863
DOI - 10.4103/jfmpc.jfmpc_1963_20
Subject(s) - atrx , idh1 , medicine , isocitrate dehydrogenase , oligodendroglioma , astrocytoma , anaplastic astrocytoma , glioma , oncology , oligodendroglial tumor , immunohistochemistry , pathology , cancer research , mutation , gene , genetics , biology , biochemistry , enzyme
Gliomas account for 45% of all intracranial tumors. Newer technologies have allowed deeper genetic and epigenetic analysis leading to the discovery of IDH (Isocitrate dehydrogenase) mutations and their association with ATRX (alpha-thalassemia/mental retardation syndrome X-linked) and p53, for better diagnosis and prognosis. In this study, we analysed their expression and correlated with various clinicopathological parameters. A follow up to prognosticate gliomas based on the molecular findings is also attempted.