Open AccessSerum kallistatin as a marker of severity of liver fibrosis in cirrhosis: A cross-sectional observational study
Author(s) -
Seetaram Singh Kularaj,
Sudhir Kumar Verma,
Vivek Kumar,
Ajay Kumar Patwa,
Shyam Chand Chaudhary,
Satyendra Kumar Sonkar,
Kamlesh Kumar Gupta,
Virendra Atam,
Sanjeev Kumar Verma,
Vivek Bhosale,
Shail Singh
Publication year - 2022
Publication title -
journal of family medicine and primary care
Language(s) - English
Resource type - Journals
eISSN - 2278-7135
pISSN - 2249-4863
DOI - 10.4103/jfmpc.jfmpc_1922_21
Subject(s) - medicine , transient elastography , cirrhosis , gastroenterology , liver biopsy , fibrosis , liver function tests , cross sectional study , liver disease , liver function , chronic liver disease , pathology , biopsy , liver fibrosis
Liver cirrhosis is among the leading causes of morbidity and mortality worldwide. Although liver biopsy is the gold standard for the assessment of liver fibrosis in cirrhosis, it has its own limitations. Therefore, noninvasive methods to detect liver fibrosis are widely preferred. However, they also have their own limitations. Thus, there is always a need to extend the battery of serum-based assays. Kallistatin is a protein synthesized primarily in the liver. As it is a negative acute-phase protein, its blood level decreases with a decline in liver function. In our study, we explored the relationship between serum kallistatin and radiological evidence of liver fibrosis by transient elastography to determine if kallistatin levels can be used as a diagnostic marker of liver fibrosis.