Open AccessAssociation of serum ferritin with COVID-19 in a cross-sectional study of 200 intensive care unit patients in a rural hospital: Is ferritin the forgotten biomarker of mortality in severe COVID-19?
Author(s) -
Vidyashree Hulkoti,
Sourya Acharya,
Sunil Kumar,
Dhruv Talwar,
Shivam Khanna,
Akhilesh Annadatha,
Sparsh Madaan,
Vinay Kumar Verma,
Vinay Sagar
Publication year - 2022
Publication title -
journal of family medicine and primary care
Language(s) - English
Resource type - Journals
eISSN - 2278-7135
pISSN - 2249-4863
DOI - 10.4103/jfmpc.jfmpc_1921_21
Subject(s) - medicine , ferritin , intensive care unit , biomarker , covid-19 , severity of illness , cytokine storm , acute phase protein , c reactive protein , gastroenterology , inflammation , disease , immunology , infectious disease (medical specialty) , biochemistry , chemistry
The COVID-19 disease caused by the SARS-CoV-2 virus, has toppled the world since first case noted in 2019, and the cases have been increasing there after. This grave effect is caused by the cytokine storm induced inflammation produced by the noxious virus. As it is an inflammatory state, various acute phase reactants are expected to raise; thus serum ferritin is contemplated to increase. Here we aim to anchor serum ferritin as a way marker for diagnosis and management of COVID-19 patients and study its role as a prognostic marker. Another aspect is the association of COVID-19 with the N: L ratio; observation has stated that higher N: L ratio results in more severe outcome. The study aimed to establish a correlation of COVID-19 severity with serum ferritin in the form of HRCT Score, N: L Ratio and Clinical Outcome in the patients admitted in Intensive Care Unit.