Open AccessEvaluation of role of interferon gamma release assays in the diagnosis of latent tuberculosis in human immunodeficiency virus-infected patients
Author(s) -
Rajender Singh,
Nazish Fatima,
Indu Shukla,
Mohammad Shameem
Publication year - 2021
Publication title -
indian journal of sexually transmitted diseases and aids
Language(s) - English
Resource type - Journals
eISSN - 2589-0565
pISSN - 2589-0557
DOI - 10.4103/ijstd.ijstd_16_20
Subject(s) - medicine , virology , latent tuberculosis , human immunodeficiency virus (hiv) , tuberculosis , interferon gamma release assay , immunology , mycobacterium tuberculosis , pathology
Tuberculosis (TB) is the most common opportunistic infection in human immunodeficiency virus (HIV)-infected individuals. The risk of eventually developing active TB from latent TB infection (LTBI) is about 10% per year in HIV-positive patients in contrast to 10% lifetime risk in HIV-negative patients. Until recently, the tuberculin skin test (TST) was the only tool available for diagnosing LTBI. Interferon-gamma release assays (IGRAs) were recently developed and address many of the limitations of TST test, especially in immunocompromised state.