Open AccessStem cell therapy in critical limb ischemia: Current scenario and future trends
Author(s) -
Arun Sharma,
Mumun Sinha,
Niraj Nirmal Pandey,
S H Chandrashekhara
Publication year - 2019
Publication title -
indian journal of radiology and imaging - new series/indian journal of radiology and imaging/indian journal of radiology and imaging
Language(s) - English
Resource type - Journals
eISSN - 0971-3026
pISSN - 0970-2016
DOI - 10.4103/ijri.ijri_385_19
Subject(s) - medicine , critical limb ischemia , stem cell therapy , cell therapy , stem cell , current (fluid) , limb ischemia , intensive care medicine , ischemia , cardiology , pathology , mesenchymal stem cell , microbiology and biotechnology , vascular disease , arterial disease , engineering , electrical engineering , biology
Critical limb ischemia (CLI) represents the most severe manifestation of peripheral arterial disease (PAD). It imposes a huge economic burden and is associated with high short-term mortality and adverse cardiovascular outcomes. Prompt recognition and early revascularization, surgical or endovascular, with the aim of improving the inline bloodflow to the ischemic limb, are currently the standard of care. However, this strategy may not always be feasible or effective; hence, evaluation of newer pharmacological or angiogenic therapies for alleviating the symptoms of this alarming condition is of utmost importance. Cell-based therapies have shown promise in smaller studies; however, large-scale studies, demonstrating definite survival benefits, are entailed to ascertain their role in the management of CLI.