Open AccessSequential MR imaging (with diffusion-weighted imaging) changes in metronidazole-induced encephalopathy
Author(s) -
Rupinder Singh,
Ramanjeet Kaur,
Pawan Pokhariyal,
Rajul Aggarwal
Publication year - 2017
Publication title -
indian journal of radiology and imaging - new series/indian journal of radiology and imaging/indian journal of radiology and imaging
Language(s) - English
Resource type - Journals
eISSN - 0971-3026
pISSN - 0970-2016
DOI - 10.4103/ijri.ijri_341_16
Subject(s) - metronidazole , medicine , magnetic resonance imaging , pons , encephalopathy , diffusion mri , dorsum , pathology , nuclear magnetic resonance , radiology , anatomy , antibiotics , chemistry , biochemistry , physics
Metronidazole-induced neuro-toxicity, though rare, is known. A characteristic spatial distribution of lesions in cerebellar dentate nuclei and dorsal pons is known. However, temporal progression of lesions on magnetic resonance imaging (MRI) has not been described previously. We describe two such cases which presented initially with splenial hyperintesity and showed progression to characterstic lesions. Both cases improved with stoppage of metronidazole.