Open AccessImmunohistochemical expression of X-linked inhibitor of apoptosis in eyelid sebaceous gland carcinoma predicts a worse prognosis
Author(s) -
Perumal Jayaraj,
Seema Sen,
PS Dhanaraj,
Romika Jhajhria,
Shalu Singh,
Vijay Kumar Singh
Publication year - 2017
Publication title -
indian journal of ophthalmology/indian journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 51
eISSN - 1998-3689
pISSN - 0301-4738
DOI - 10.4103/ijo.ijo_399_17
Subject(s) - xiap , inhibitor of apoptosis , immunohistochemistry , medicine , apoptosis , cancer research , pathology , oncology , caspase , biology , programmed cell death , biochemistry
Overexpression of the inhibitors of apoptosis proteins have been demonstrated in a variety and of solid tumors including melanomas and nonmelanomas skin cancers. X-linked inhibitor of apoptosis protein (XIAP) is an inhibitor of apoptosis which prevents apoptosis by inhibiting caspases 9, 7, and 3. The prognostic value of XIAP in sebaceous gland carcinoma (SGC) remains unexplored.